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Farmakoterapie tromboembolických stavů, 4. aktualizované vydání
Tromboembolické stavy patří svou prevalencí i následky k nejzávažnějším tématům současné medicíny i celého zdravotnického systému. Plicní embolizace u nás postihne ročně přes 6000 osob, přičemž mortalita dosahuje 7 až 11 %. V současnosti přibývá nemocných, kteří jsou buď krátkodobě – např. preventivně předoperačně – léčeni antitrombotiky, nebo na antitrombotické léčbě zůstávají dlouhodobě (při prevenci tromboembolických komplikací u fibrilace síní, po náhradách chlopní, v rámci léčby žilního tromboembolismu).
Čtvrté vydání úspěšné publikace dvou předních odborníků v oblasti angiologie a kardiologie přináší nejnovější poznatky v medikamentózní léčbě tromboembolických stavů, včetně podrobného seznámení s novými látkami na farmaceutickém trhu.
Kniha je určena jednak internistům a kardiologům, řadu terapeutických doporučení využijí rovněž praktičtí lékaři.
Mona’s Eyes
THE 1 MILLION COPY BESTSELLER
"Shockingly good."?The Daily Mail
Ten-year-old Mona is about to lose her sight forever. Her beloved grandfather has only fifty-two Wednesdays to visit fifty-two works of art and commit to memory “all that is beautiful in the world” before this happens.
While the doctors can find no explanation for Mona’s brief episode of blindness, they agree that the threat of permanent vision loss cannot be ruled out. The girl’s grandfather, Henry, may not be able to stop his granddaughter from losing her sight, but he can fill the encroaching darkness with beauty. For every Wednesday during a year, the pair will visit a single masterpiece in one of Paris’s renowned museums. From Botticelli to Basquiat, Mona learns how each artist’s work shaped the world around them. In turn, the young girl’s world is changed forever by the power of their art.
Under the kind and careful tutelage of her grandfather, Mona learns the true meaning of generosity, melancholy, love, loss, and revolution. Her perspective will never be the same?nor will the reader’s.
READER REVIEWS
"This is a novel that will touch many."
"Hypnotic."
"This beautiful, well-researched book is captivating."
"A pleasure read!"
"I loved every page."
"Heartwarming and refreshing."
Invasion Prague 68
Josef Koudelka’s landmark photographs of the Prague Spring and the resulting Soviet invasion.Josef Koudelka never planned to become a conflict reporter. That all changed on the night of 21 August, when Soviet tanks entered Prague, ending the short-lived political liberalization in Czechoslovakia. 'I wasn’t a reporter,' Koudelka recalls. 'I had never photographed anything that you would call ""news"". Suddenly, for the first time in my life, I was confronted with that kind of situation. I responded to it. I knew it was important to photograph, so I photographed.' For fear of repercussions, Koudelka originally published the images under the pseudonym 'PP' (Prague photographer). The intensity and significance of the images earned the still-anonymous photographer the Robert Capa Gold Medal Award. Sixteen years would pass before Koudelka could safely acknowledge authorship.Now reissued in a hardback format, this bold new edition will bring these vital photographs back to the public eye, standing as a stark reminder of the importance of bearing witness to violence and brutality.
Sardinie - turistický průvodce
Poznejte Sardinii – jedinečný ostrov, kde se divoká příroda snoubí s autentickou kulturou a každá cesta se mění v nezapomenutelný zážitek.
Od členitých mysů a odlehlých písečných pláží až po zalesněné hory a rozlehlou divočinu – Sardinie je jedinečný středomořský ostrov, který překvapí i toho nejzkušenějšího cestovatele. Toužíte-li poznat kouzlo Karibiku či Tahiti, aniž byste opouštěli Evropu, měli byste zamířit právě sem. Chcete objevovat skryté poklady středověkého umění v nenápadných kostelích, ztratit se v živém bludišti úzkých uliček hlavního města Cagliari, ochutnávat výtečné víno, které se zde pěstuje několik tisíc let, nebo si zaplavat v tyrkysových vodách zátok na pobřeží? Tento plně aktualizovaný průvodce Rough Guide vám bude na vašich cestách nejlepším společníkem.
Z prestižní britské řady Rough Guides.
Vietor fúka do klobúka
Ak má niekto prievan v hlave, je to galiba. No ak by niekomu do nej niečo (múdre) len tak nafúkalo, bolo by to super. Nad básničkami v tejto knihe môžu malí čitatelia rozmýšľať, či sa vietor spod klobúka dostane aj inde. A pri hádankách, ktoré sú tiež jej súčasťou, si môžu cibriť svoj um a myslenie.
A Particularly Nasty Case
When a toxic hospital consultant dies of a heart attack, fellow doctor Eitan Rose smells foul play. Nobody else does though, including some quite crucial players like the police and the coroner. So when another senior doctor dies in similar circumstances, he's determined to prove there's more to these deaths than meets the eye.But following time off for his mental health, Eitan's friends and colleagues begin to question his judgement as his chaotic investigation and equally chaotic life spiral simultaneously out of control. Is he making a career-ending mistake, or could there genuinely be a killer stalking the wards?A deathly funny mix of mystery, murder and medicine, A PARTICULARLY NASTY CASE is the brilliantly original debut novel from Adam Kay, BAFTA-winning author of multi-million global bestseller THIS IS GOING TO HURT.PRAISE FOR ADAM KAY'Richly comic. Kay's writing is a constant pleasure' Daily Express'Spectacularly brilliant' Cathy Rentzenbrink'Piercingly funny' Tanya Gold, Daily Telegraph'One of Britain's funniest writers' Grace Dent'Extraordinary' Observer
Bajk: Dve kolesá, ktoré zmenili svet
Kniha pre veľkých i malých nadšencov cyklistiky.
Keď sedíte na bicykli, takpovediac skoro lietate. Vznášate sa vo vzduchu, a pritom ste na zemi. Takmer každý si spomenie, ako sa na ňom spustil prvýkrát úplne sám. Čím to je? Ako vôbec vznikol nápad zostrojiť bicykel? Čo tento dvojkolesový kôň vlastne robí s naším telom a pocitmi, s našimi výletmi krajinou i mestom, kde žijeme?
Úplne všetko o bicykloch nájdete v tejto bohato ilustrovanej knihe. V nej vám autori vyrozprávajú príbeh tohto nenahraditeľného dopravného prostriedku, ktorý dokáže meniť svet. Spoznáte jeho konštrukciu aj históriu - od dreveného odrážadla cez velocipéd až po dnešné holandské, horské a cestné bicykle či BMX. Bicykel je najekologickejší dopravný prostriedok, jeden z najlepších priateľov človeka (hneď po psovi a mačke, samozrejme). Slúži malým aj veľkým na každodenných cestách, ale aj pri neobyčajných výpravách. Najdôležitejšie však je, že nám dokáže sprostredkovať pocit úplnej slobody.
Anna, cesta ze Sudet
Anna Lesná dospívá ve světě, který se dramaticky mění. Z dívky poznamenané válečnými roky v Sudetech se stává mladá žena, jež se navzdory svému německému původu snaží vybojovat vlastní budoucnost. Jenže do života jejího i jejích blízkých se neúprosně vkrádá nová hrozba – nástup komunismu. Povinné brigády, tlak na vstup do strany, šeptanda o politických procesech a trestech smrti. Každý krok může být osudový. A přesto Anna odmítá ustoupit a vzdát se svých snů, touží studovat keramickou školu, složit maturitu a najít lásku.
Na pozadí proměňující se společnosti se odvíjí i další osudy – Lída Čechová prožívá hluboký cit ke studentovi techniky Miroslavovi, jenž se netají odporem k nastupujícímu režimu. Stačí však jediný čin a jeho život se ocitá v rukou moci, která neodpouští.
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Pohledný ďábel
Gia: Netvor z nočních můr se vplížil do reality maskovaný jako můj šéf. Tatum Blackthorn je zosobněný Lucifer. Když odhalí moje slabé místo, udělá mi nabídku, kterou nemůžu odmítnout, a stanu se jeho ženou. Tate: Mám několik zálib a jednou z nich je zničit Giu Bennettovou. Pomalu. Trpělivě. Ta posedlost mojí asistentkou má důvod, ale žádné hranice. Jenže když se zapletu do války s mafií, není v ohrožení jen můj život. V šachové partii chrání král královnu. I za cenu toho, že obětuje celou svoji říši.
Odložené líbánky
Irisin svatební den Iris se stane internetovou senzací z těch nejhorších důvodů. Po hádce s nevěrným snoubencem odjíždí sama na líbánky na Kauai, odhodlaná začít znovu. Tam omylem sdílí bungalov se sexy cizincem Romanem Maguirem, hvězdou NFL, která skrývá vlastní tajemství. Co začne jako krátký románek v ráji, rychle přeroste v něco hlubšího. Jenže minulost, sláva i veřejná ostuda mohou jejich vztah zničit.
Na sklade 1Ks
19,99 €
Tvorivé leto na Santorini
Tri ženy. Jedno leto na Santorini. A príbehy, ktoré im navždy zmenia život.
Keď bestsellerová autorka Jessica Rose prijme pozvanie viesť spisovateľský pobyt na oslnivom ostrove Santorini, dúfa, že medzi bielymi domčekmi, modrými kupolami a zlatými západmi slnka znovu nájde stratenú inšpiráciu. Pred minulosťou však nemožno utekať donekonečna. Zina sa na ostrov vracia po rokoch s jediným cieľom – premeniť svoj sen na úspešné podnikanie. Santorini je jej domovom, no zároveň miestom plným spomienok, ktoré nikdy celkom nevybledli. A Karmela? Tá túži napísať knihu, na ktorú bude jej matka hrdá. Netuší však, že práve toto leto jej prinesie oveľa viac než len príbeh na papieri.
A Summer Country Escape
The next book in the Country Escapes series!
You don't know what you've got till it's gone…
Bets Fowler has always been perfectly fine living her life firmly within the borders of her tiny village. But when her ex, Jack, returns and is suddenly everywhere she goes, she realises just how small the parameters of her existence have become, and starts to step outside her comfort zone.
Jack Ashcroft has always sought out a bigger life than he thought Wilsgrave could afford, but when a knockback sends him home, and back into Bets' orbit, he comes to see that the world he once inhabited has a lot more to offer than he ever realised, and that leaving might have been the biggest mistake he ever made.
Now, as Bets and Jack find themselves thrown together at every turn, the exes see what was and what could be in an entirely new light…
Daybreak - Sorrowsong University 2
Betrayal. Heartbreak. Deadly New Threats. Welcome Back to Sorrowsong University . . .
Alex Corbeau-Green's world is burning. Ophelia Winters is desperate to prove she didn't start the fire . . .
Ophelia came to the elite Sorrowsong University to destroy Alex and his family. But that was before she knew him. Before their love became each of their reasons for living.
Now, after an unthinkable betrayal and the disappearance of his father, Alex is forced back to New York. He is desperate to forget what they had - and salvage his empire. Ophelia is left behind in the Scottish Highlands, reeling, alone . . . and watched.
When a new, anonymous tormentor threatens to reveal evidence that Ophelia and Alex committed a murder on campus, it's clear they're going to need each other once again. But can they find a way to trust each other and repair the love they had?
And even if they can - will it be enough this time to keep them alive?
From Autumn Woods, Daybreak is the stunning conclusion to the Sunday Times bestseller Nightshade now - a dark academia romance brimming with snarky banter, shadowy figures, and sizzling tension.
The Plunge
A globe-spanning narrative adventure about how the euphoria of cold water can transform - and even extend - your life.
'Mesmerizing. Chris Ballard does a deep dive into one of the most controversial health, fitness, and athletic crazes of our time. I still loathe cold water, but I loved this book.' Adam Grant, #1 New York Times bestselling author of Think Again and Hidden Potential
Lifelong athlete and Sports Illustrated writer Chris Ballard worried his days of exercise were numbered. Then he received a fateful text message about a trend taking hold around the world: submerging in freezing cold water.
It wasn't only thrill seekers or wellness gurus extolling its power. Swimmers have long known that when paired with cold, their sport delivers extraordinary rewards; now, modern research has shown that just a few minutes in cold water can deliver remarkable benefits: heightened energy and focus, reduced inflammation, and relief from depression and anxiety.
In The Plunge, Ballard travels to laboratories and swims in waters around the world, from Portsmouth to the Pacific, tracing the roots of cold water swimming in ancient practices largely lost in the modern world.
He immerses himself in the growing tribe of cold-water junkies of all ages, shapes and nationalities, from pioneers like Lynne Cox to visionaries like Ram Barkai, whose audacious dream of getting ice swimming into the Olympics edges closer to reality.
And, from cold plunging to open water swimming to ice swimming, he tests his limits in this extreme sport, eventually becoming a US national champion, his body and mind transformed along the way.
Blending history, cutting-edge science, colourful characters, and propulsive narrative storytelling, it's a rollicking, eye-opening adventure that reveals how a single act - stepping into cold water - can unlock resilience, connection, meaning and joy.
Howl
Drawn from fifty years of experimental, ground-breaking verse, this selection, in Ginberg's words 'summarizes what I deem most honest, most penetrant of my writing'. It includes the major poems 'Howl' and 'Kaddish', but also important early work, songs, uncollected poems and notes from the author that go beyond his iconic Beat Generation image. Intensely personal and incandescently brilliant, Howl and Other Poems is a core Ginsberg text, and celebrates 'Holy the supernatural extra brilliant intelligent kindness of the soul!'
Selected Poems 1965-2005
'Tell me, what is it you plan to do
with your one wild and precious life?'
One of America's best loved poets, Mary Oliver is also among nature's most brilliant and devoted observers, whose words ask us to live with our eyes open wider. This luminous selection brings together her best-known works from across her career.
'Oliver's poems are … as genuine, moving, and implausible as the first caressing breeze of spring' New York Times Book Review
'Mary Oliver's poetry is fine and deep; it reads like a blessing' Stanley Kunitz
'Just a few seemingly simple phrases perfectly express what we need to know just then, in that moment' Oprah Winfrey
'It doesn't feel like you have to take a seminar in order to understand Mary Oliver's poetry. She's speaking directly to you as a human being' Ruth Franklin, The New Yorker
A Month in the Country
J. L. Carr's beautiful portrayal of the countryside and the healing it brings, in an irresistible Little Clothbound Classics edition designed by Coralie Bickford-Smith
'One of the best books I've ever read' Richard Osman
'Unlike anything else in modern English literature' D.J. Taylor, Spectator
A damaged survivor of the First World War, Tom Birkin finds refuge in the quiet village church of Oxgodby where he is to spend the summer uncovering a huge medieval wall-painting. Immersed in the peace and beauty of the countryside and the unchanging rhythms of village life he experiences a sense of renewal and belief in the future. Now an old man, Birkin looks back on the idyllic summer of 1920, remembering a vanished place of blissful calm, untouched by change, a precious moment he has carried with him through the disappointments of the years. Adapted into a film starring Colin Firth, Natasha Richardson and Kenneth Branagh, A Month in the Country traces the slow revival of the primeval rhythms of life so cruelly disorientated by the Great War.
Animal Farm
One of the most celebrated works of modern literature, Animal Farm is George Orwell's satire on the Russian Revolution of 1917 and Stalin's subsequent rule. It tells the story of the animals of Manor Farm, as they rise up against the drunken farmer Mr Jones and the ensuing leadership battle between two pigs, Snowball and Napoleon. They set in motion their 'system of thought', Animalism, a clear play on Communism, with seven tenets including, 'All animals are equal but some animals are more equal than others.'
This elegant pocket hardback edition has real collector's appeal, featuring the classic, unabridged text, a facsimile of Orwell's signature on the title page, silver gilded page edges and beautifully designed endpapers. Part of the Arcturus Ornate Classics series this book makes wonderful gift for any lover of classic literature.
ABOUT THE SERIES: Arcturus Ornate Classics are beautifully bound editions of iconic literary works across history. These compact, foil-embossed hardbacks are printed using deluxe ivory paper and make the perfect gift.
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Najpredávanejší autori v tejto kategórii: Dominik Dán, Joanne K. Rowling, Freida McFadden, Elle Kennedy, Stephen King.





























