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For Blood and Money - Billionaires, Biotech, and the Quest for a Blockbuster Drug
A gripping business narrative and scientific thriller about what it takes to bring a wonder drug to market?and save countless lives.
For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug, and how members of the core team?denied their share of the profits?went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.
In the multibillion-dollar business of biotech, where pharmaceutical companies, the government, hedge funds, and venture capitalists have spent billions on funding, experimentation, and treatments, a single molecule can stop cancer in its tracks?and make the people who find that rare molecule astonishingly rich. For Blood and Money follows a small team at a biotech start-up in California, who have found one of these rare molecules. Their compound, known as a BTK inhibitor, seems to work on a vicious type of leukemia. When patients start rising from their hospice beds, the team knows they’re onto something big.
What follows is a story of genius, pathos, and drama, in which vivid characters navigate a world of corporate intrigue and ambiguous morality. Vardi’s narrative immerses readers in the recent explosion of biotech start-ups. He describes the scientists, doctors, and investors who are risking everything to develop new, life-saving treatments, and introduces suffering patients for whom the stakes are life-or-death. A gripping nonfiction read, For Blood and Money illustrates why it’s so hard to bring new drugs to market, explains why they are so expensive, and examines how profit-driven venture capitalists are shaping the future of medicine.
Vypredané
28,45 €
29,95 €
La lunga strada di sabbia
The extraordinary picture story by Paolo Di Paolo, accompanied by texts by Pier Paolo Pasolini which documents and narrates Italians on vacation during Summer 1959, from the Tyrrhenian to the Adriatic Sea; from Ventimiglia to Trieste (from the western to the eastern border). In 1959 Paolo Di Paolo is a 34-year-old photographer collaborating with the cultural weekly magazine Il Mondo directed by Mario Pannunzio, and the widely distributed magazine Tempo. Pier Paolo Pasolini is a promising 37-year-old writer who had published The Best of Youth, The Street Kids and A Violent Life.He is not yet a film director. In Italy, the "economic miracle" has just begun. The newspapers tend to offer to Italian families a microcosm of mythical characters as a diversion to the dullness and fear of war, emigration, and poverty.
Arturo Tofanelli, editor in chief of the monthly Successo and the weekly Tempo, entrusts the two young men, Di Paolo and Pasolini, who did not know each other, to do a report on the Italian Summer Holidays that will be published by Successo magazine in three issues (July, August and September 1959). The writer and the photographer set off from Ventimiglia together, with the plan of travelling through the coasts of Italy to the south and climbing up to Trieste. But they have different visions.
"Pasolini was looking for a lost world of literary ghosts, an Italy that no longer existed," recalls Di Paolo. "I was looking for an Italy that was looking to the future. I conceived the title The Long Road of Sand meaning the strenuous road traveled by Italians to reach well-being and holidays after the War." A complex, delicate partnership is born between Pasolini and Di Paolo, they will travel together only the first stage of this journey, but this experience would later be consolidated in mutual respect and trust.
Text in English, German and Italian.
Vypredané
72,15 €
75,95 €
The Apple - Crimson Petal Stories
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The Crimson Petal and the White is one of the best-loved novels of recent years. Now a major BBC TV drama, it captured hearts and left readers desperate for more. In The Apple, Faber returns to Silver Street to find it still teeming with life, and conjures further tantalising glimpses of Sugar, Clara, Mr Bodley and many other favourites.
Vypredané
11,88 €
12,50 €
Rihanna - And the Clothes He Wears
- A guide to the style of Rihanna, a 21st-century fashion icon
- Over 100 pictures of Rihanna and designers who have influenced her sartorial taste
- The perfect gift for fans and fashionistas
“I grew up on a really small Island, and I didn't have a lot of access to fashion, but as far as I could remember, fashion has always been my defence mechanism. Even as a child I remember thinking, she can beat me, but she cannot beat my outfit.” - Rihanna, accepting the CFDA Fashion Icon of the Year Award in 2014.
From the author of the runaway bestseller Harry Styles and the Clothes He Wears comes a new, fresh look at style icon Rihanna.
Rihanna has learnt how to define her own terms whatever she does – whether in the worlds of fashion, music, beauty, philanthropy, business, or activism, she is both muse and creative, a collaborator and pioneer. To date she has 135 million Instagram followers and counting. In 2022 at the age of 34, largely because of her Fenty Beauty empire, she became Forbes' youngest self-made billionaire.
But it is her personal wardrobe and the way she wears it that embodies Rihanna's charisma, integrity, and humor most: everything she does reflects what she wears herself. She is a risk-taker, but as she said on the red-carpet in 2014 “you will never be stylish if you don't take risks.” The gamble has paid off. Rihanna's mix-and-match method of wearing high fashion and streetwear, young designers and vintage, hip-hop classics, and avant-garde custom-made pieces, has meant that she has equal footing in both the music and fashion industries. Chairman and CEO of the LVMH group, Sidney Toledano says she is: “a style icon for today's generation”.
The breadth of Rihanna's fashion knowledge and style is astounding. In Rihanna and the Clothes She Wears, Terry Newman steps into the world of this fashion icon by examining her style. From couture catwalks to her own empire Fenty, political statements to high street casual, this chic book fizzles with facts about Rihanna's styling choices, presenting the star's most revered looks. With quotes from key designers, this is the perfect gift for any fan.
Ultimate Spider - man a spol. 12
A je to tu! Dvanácté číslo Ultimate Spidermana a spol., ideální číslo nejen pro věrné fandy, ale i pro ty, kteří doteď váhali a chtějí to zkusit. Protože tady se rozjíždí hned dva nové příběhy!
Spider-Manovi, který minule zabodoval s doktorem Ockem, se vrací jeho starý soupeř... vlastně jeho skoro první soupeř. Green Goblin. A je chytřejší, šílenější a nebezpečnější než kdy předtím. A zatímco vyraží Petr Parker na setkání se svou nemesis, X-Meni vyráží na světové turné. Profesor X bude mít šňůru přednášek o mírumilovném soužití, který se, jak správně hádáte, změní v masakr. Z tajemného sanatoria utekl tajemný mutant, který má s profesorem nevyřízené účty. A do toho se objevují i první velké problémy v týmu.
Takže pokud ještě USM nekupujete, neváhejte. Uvidíte, jak vypadá klasický superhrdinský komiks bez brzd - ve světě, kde se může stát cokoliv a kde dostávají slavné hrdiny na starost ještě slavnější autoři... jako třeba Brian Michal Bendis (Powers, Daredevil, Sam a Twitch) či Mark Millar (Kick-Ass - Nářez, Wanted, Superman: Rudá hvězda, Ultimates). Navíc v tomhle čísle najdete i obsáhlý materiál o dějinách klasického Spider-Mana a další část historie X-Menů
The Cult Of We: Wework And The Great Start-Up Delusion
The definitive inside story of WeWork, its audacious founder, and the company's epic unravelling from the journalists who first broke the story wide open.
In 2001, Adam Neumann arrived in New York after five years as a conscript in the Israeli navy. Just over fifteen years later, he had transformed himself into the charismatic CEO of a company worth $47 billion. With his long hair and feel-good mantras, the six-foot-five Neumann looked the part of a messianic Silicon Valley entrepreneur. The vision he offered was mesmerizing: a radical reimagining of work space for a new generation. He called it WeWork.
As billions of funding dollars poured in, Neumann's ambitions grew limitless. WeWork wasn't just an office space provider; it would build schools, create cities, even colonize Mars. In pursuit of its founder's vision, the company spent money faster than it could bring it in. From his private jet, sometimes clouded with marijuana smoke, the CEO scoured the globe for more capital but in late 2019, just weeks before WeWork's highly publicized IPO, everything fell apart. Neumann was ousted from his company, but still was poised to walk away a billionaire.
Calling to mind the recent demise of Theranos and the hubris of the dotcom era bust, WeWork's extraordinary rise and staggering implosion were fueled by disparate characters in a financial system blind to its risks. Why did some of the biggest names in banking and venture capital buy the hype? And what does the future hold for Silicon Valley 'unicorns'? Wall Street Journal reporters Eliot Brown and Maureen Farrell explore these questions in this definitive, rollicking account of WeWork's boom and bust.
Vypredané
18,00 €
18,95 €
Ve Věštné běli
Náš výbor Ve věštné běli (31 básní) se omezuje jen na básníkovu lyriku. Usiluje o nalezení průniku nejživotnější části Mallarméova básnického odkazu a šťastných překladatelských řešení. A co víc: obraz básníka tak skoupého na slovo o sobě, chce zahlédnout v zrcadlové síni výroků jeho významných předchůdců, současníků i potomků. Knihu doprovází 31 celostránkových reprodukcí děl impresionistů, Mallarméových současníků (ilustrace Edgar Degas, Albert Dubois-Pillet, Henri Fantin-Latour, Édouard Manet, Claude Monet, Odilon Redon, Auguste Renoir, Alfred Sisley, Félix Vallotton, James Abbott McNeill Whistler), a je vybavena rozsáhlým esejem básníka Vladimíra Janovice, doslovem univerzitní profesorky Jany Nechutové a ediční poznámkou Vladimíra Janovice
Vypredané
11,16 €
11,75 €
Video Game of the Year
Breaking down the 40-year history of the world's most popular art form, one video game at a time
Pong. The Legend of Zelda. Final Fantasy VII. Rock Band. Fortnite. Animal Crossing: New Horizons. For each of the 40 years of video game history, there is a defining game, a game that captured the zeitgeist and left a legacy for all games that followed. Through a series of entertaining, informative, and opinionated critical essays, author and tech journalist Jordan Minor investigates, in chronological order, the innovative, genre-bending, and earth-shattering games from 1977 through 2022. Minor explores development stories, critical reception, and legacy, and also looks at how gaming intersects with and eventually influences society at large while reveling in how uniquely and delightfully bizarre even the most famous games tend to be.
From portly plumbers to armor-clad space marines and the speedy rodents in between, Video Game of the Year paints individual portraits that, as a whole, give readers a stronger appreciation for the vibrant variety and long-lasting impact of this fresh, exciting, and massively popular art form. Illustrated throughout with retro-inspired imagery and featuring contributions from dozens of leading industry voices, including New York Times bestselling author Jason Schreier (Blood, Sweat, and Pixels; Kotaku), Max Scoville (IGN), Rebekah Valentine (IGN), Blessing Adeoye Jr. (Kinda Funny), and Devindra Hardawar (Engadget), this year-by-year anthology is a loving reflection on the world's most popular art form.
Featured Games: 1977 - Pong; 1978 - Space Invaders; 1979 - Speed Freak; 1980 - Pac-Man; 1981 - Donkey Kong; 1982 - Pitfall!; 1983 - Dragon's Lair; 1984 - Tetris; 1985 - Super Mario Bros.; 1986 - Dragon Quest; 1987 - The Legend of Zelda; 1988 - Mega Man 2; 1989 - SimCity; 1990 - The Secret of Monkey Island; 1991 - Sonic the Hedgehog; 1992 - Wolfenstein 3D; 1993 - NBA Jam; 1994 - Super Street Fighter II Turbo; 1995 - Donkey Kong Country 2; 1996 - Super Mario 64; 1997 - Final Fantasy VII; 1998 - Metal Gear Solid; 1999 - System Shock 2; 2000 Counter-Strike; 2001 - Halo: Combat Evolved; 2002 - Grand Theft Auto: Vice City; 2003 - The Legend of Zelda: The Wind Waker; 2004 - World of Warcraft; 2005 - Resident Evil 4; 2006 - Wii Sports; 2007 - Rock Band; 2008 - Spore; 2009 - Uncharted 2; 2010 - Super Meat Boy; 2011 - Minecraft; 2012 - Telltale's The Walking Dead; 2013 - Depression Quest; 2014 - Destiny; 2015 - The Witcher 3; 2016 - Pokémon Go; 2017 - Fortnite; 2018 - Super Smash Bros. Ultimate; 2019 - Sekiro: Shadows Die Twice; 2020 - Animal Crossing: New Horizons; 2022 - The Stanley Parable: Ultra Deluxe
Vypredané
24,65 €
25,95 €
Občanské soudní řízení Kniha III.
Komentář zpracovaný širokým autorským kolektivem pod vedením soudcem JUDr. Jaromírem Jirsou představuje nové pohledy na české civilní procesní právo, v jehož středu stojí občanský soudní řád. Rozsáhlý komentář vychází z bohatých praktických zkušeností soudců, kteří tvoří většinu členů autorského kolektivu. Je výjimečný rovněž tím, že autoři text komentáře doplnili přibližně 2000 judikátů, řadou grafů, tabulek, příkladů a vzorových dokumentů.
Vypredané
66,98 €
70,50 €
Hans Christian Andersen's Fairy Tales
A beautiful clothbound hardback gift edition of the world's most celebrate fairy tales.
Every man's life is a fairy tale, written by God's fingers. - Hans Christian Andersen.
A delightful selection of stories from Hans Christian Andersen, translated by the eminent writer and critic, Naomi Lewis. All the best-known and most-loved stories are included - 'Thumbelina', 'The Snow Queen', 'The Emperor's New Clothes' etc, as well as the less familiar - 'The Goblin at the Grocer's' and 'Dance, Dolly, Dance'.
Puffin Clothbound Classics is a series of much-loved stories from classic children's literature, brought together by Puffin Books in beautiful hardback volumes.
Vypredané
18,95 €
19,95 €
The Key to Happiness
Happiness is just around the corner with this practical guide from happiness researcher Meik Wiking
Meik Wiking understands happiness better than anyone. In his role as Founder and CEO of the world's only Happiness Research Institute, he has travelled the globe interviewing the world's happiest people to discover the key components of happiness.
In The Key to Happiness, Meik explores the hidden treasures which can improve your happiness, and divides them into the six building blocks of happiness; togetherness, money, health, kindness, trust and freedom. For each happiness block he offers practical tips: for togetherness he encourages setting up a mini-library in your apartment building or starting a tool-sharing programme in your street; for kindness he suggests leaving a surprise gift on a stranger's doorstep, helping a tourist find their way or telling someone who means a lot to you that they do.
Drawing on social science, case studies and Meik's original research, this practical guide shows us that you can find happiness in a simple way of life. While Meik has travelled across the globe to discover the secrets of the world's happiest people, this book shows us that you can be just as happy where you are.
This book is the perfect guide on how to survive and navigate the modern world with a smile on your face.
Vypredané
10,93 €
11,50 €
Lidská práva
Problematika lidských práv patří v posledních desetiletích k nejčastěji zmiňovaným jak v propagandě, tak i v teorii politiky a zůstává středem pozornosti mnoha jednotlivců i organizací. Vlastní idea lidských práv v sobě skrývá silné představy spravedlnosti. Kniha je výrazným příspěvkem do diskuse o lidských právech. Autor zdůrazňuje, že lidská práva jsou především projektem nové, spravedlivější globální civilizace, jsou programem a strategií, opírající se o humanistickou filosofii.
Vypredané
8,12 €
8,55 €
Cheers to TV
The duo behind Cocktails of the Movies returns with dozens of delicious and easy-to-prepare drinks that will elevate your next TV watch party.
The perfect pop culture pairing, this collection of drinks inspired by iconic television characters blends old and new, spicy and sweet, strong and mellow.
Cheers to TV connects sixty cocktails to stars of the small screen. Some are invented specifically for that character, such as the Bloody Ending, inspired by Game of Thrones’ Daenerys Targaryen, or the Stringer Bell, an ode to The Wire. Others deliver a TV twist to an established cocktail—a Rusty Nail for Better Call Saul’s titular hero, for instance. Some are cocktails created by the show itself—Absolutely Fabulous’ Stoli-Bolli is sure to outlive its boozy inventor Patsy Stone. There are mocktails like the Banana Stand (honoring George Michael Bluth from Arrested Development), coffee-tinged drinks such as the Central Perk (for Friends’ Rachel), and even a rainbow slushie inspired by Pose’s Blanca Evangelista.
Along with clever, original illustrations, straightforward recipes, and engaging texts about the shows and characters, the authors cover the mixology basics: bar equipment; types of spirits, liqueurs, juices, and bitters; garnishes and glassware.
Whether you prefer appointment television or an hours-long stream-a-thon, this book will up the enjoyment factor. Just remember: sip the cocktail, binge the show.
Batman: One Dark Knight
Iconic Batman artist Jock delivers a bare-knuckle brawl through the blacked-out streets of Gotham!
All they had to do was get him across town.
It was the sort of mission Batman had run a thousand times. From high above the sweltering summer streets of Gotham, Batman would escort the GCPD as the dangerous metahuman super-villain known as E.M.P. was transferred from a temporary holding cell to his permanent home at Blackgate Prison in Gotham Harbor. E.M.P.’s electrical powers posed a dangerous threat, but the situation was well in hand.
Until it wasn’t.
Now every light in Gotham is out, the police have been knocked into disarray, and a broken, bleeding Batman must fight his way to Blackgate, block by block, dragging E.M.P. behind him. But it’s not just the gangs who want to make life difficult for him. The dark corners of Gotham contain many surprises…and E.M.P. has many more shocks to deliver before the night is through!
One of the most iconic Batman artists of the 21st century, the incomparable Jock (THE BATMAN WHO LAUGHS, BATMAN: THE BLACK MIRROR), has focused all his storytelling powers on the tale of one very, very dark night in Gotham City. It’s always darkest before the dawn—if it ever comes…
Collects Batman: One Dark Knight #1-3.
Vypredané
22,33 €
23,50 €
Batman & Robin Vol. 1: Batman Reborn
Named by James Gunn as an influence for Gods and Monsters, the first chapter of the new DC Universe film and television slate! This story inspires the upcoming film THE BRAVE AND THE BOLD.
Grant Morrison and Frank Quitely, the creative team of ALL STAR SUPERMAN, reunite to tell the adventures of the all-new Batman & Robin.
The new Dynamic Duo hit the streets with a bang in their new flying Batmobile as they face off against an assemblage of villains called the Circus of Strange.
Vypredané
22,33 €
23,50 €
Joker: One Operation Joker Vol. 2
The Joker is about to realize that raising kids is no joke!
Batman, the epitome of justice, and his eternal nemesis, the Joker, have been engaged in an escalating battle in the streets of Gotham City. However, everything changes one fateful night when an unforeseen accident miraculously turns Batman into a helpless infant!
Now, the Joker is detemined to raise the baby to eventually reclaim his mantle as Batman but finds himself overwhelmed with the challenges of nuturing a child.
This officially authorized DC Comics series has captured the empathy of parents across generations. Prepare for a hilarious exploration of the Joker's woefully inadequate parenting skills in volume 2!
Vypredané
11,88 €
12,50 €
Limity autorskoprávní ochrany
Monografie se zabývá analýzou a srovnáním problematiky limitů autorskoprávní ochrany v České republice a v zahraničí. Středem pozornosti jsou obecné (definiční) limity a výjimky a omezení. Kniha klade zvláštní důraz na komparaci a vyhodnocení právních názorů a závěrů, které jsou v současnosti aktuální nebo o kterých se vede diskuze.
První část se věnuje vymezení limitů autorskoprávní ochrany a obecným limitům, zejména principu jedinečnosti, dichotomii myšlenky a vyjádření, době trvání majetkových autorských práv a principu vyčerpání autorského práva. Zabývá se také vyvážeností autorského práva a ostatních přirozených práv.
V druhé části autor analyzuje, srovnává a vyhodnocuje ústavní, mezinárodní a unijní rámec právní úpravy výjimek a omezení, systém výjimek a omezení v českém autorském právu a judikatuře, výjimku pro účely parodie, karikatury, parafráze, koláže. Druhou část zakončuje budoucí vývoj v oblasti výjimek a omezení.
Vypredané
17,41 €
18,33 €
Amazing Spider-man Epic Collection: The Goblin Lives
It's horror on the home front when Peter Parker becomes the third wheel to comics' oddest couple! Yes, Aunt May has found a new special friend: Dr. Otto Octavius! While a klonk on the head may help Spidey forget that one, teaming up with Doc Ock isn't going to improve his image as Public Enemy No. 1! Spidey battles his way through Ka-Zar, the Vulture and Mysterio, but his deadliest battle is yet to come: Norman Osborn has regained his memory, and the Green Goblin has returned! Spider-Man's most dangerous foe, the only villain to uncover his identity as Peter Parker, is back with a vengeance - and the two will face off in a gigantic, 58-page magazine masterpiece!
Collecting AMAZING SPIDER-MAN (1963) #53-67, SPECTACULAR SPIDER-MAN (1968) #1-2, MARVEL SUPER-HEROES (1967) #14, and material from NOT BRAND ECHH #6 and #11.
Vypredané
49,35 €
51,95 €