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Základní a aplikovaná farmakokinetika


Publikace je určena jak pro pregraduální vzdělávání, tak pro postgraduální vzdělávání mediků a farmaceutů, popřípadě dalších oborů přírodních věd. Poskytuje nejen obecné základy, ale i praktické návody a výpočty potřebné pro dávkování konkrétních léků v klinické praxi. Publikace nabízí oproti ostatním publikacím hlubší, extenzivnější výklad dané problematiky a zejména klinickou aplikaci.
Na sklade 1Ks
24,86 €

Pamětihodnosti panství Náchod sepsané Janem Müllerem


Rukopis Pamětihodnosti panství Náchod sepsaný v roce 1842 dlouholetým panským důchodním Janem Müllerem (1773–1861), představuje mimořádné svědectví o životě na jednom z nejvýznamnějších východočeských panství přelomu 18. a 19. století. Autor, který působil ve službách náchodské vrchnosti více než půl století, zachytil hospodářský, správní i společenský život panství s přesností úředníka a vnímavostí pozorovatele své doby. Müllerovy zápisky odhalují nejen chod vrchnostenské kanceláře, ale i atmosféru společenských proměn a kulturního rozkvětu. Popisuje spory o piccolominské dědictví, dobu vlády Petra vévody Kuronského a jeho dcery Kateřiny vévodkyně Zaháňské, tajná jednání protinapoleonské koalice v Ratibořicích i uvedení Mozartovy opery Don Giovanni v náchodském zámeckém divadle. Vedle významných historických momentů zaznamenává i každodenní realitu úředníků, duchovních a učitelů, čímž podává plastický obraz života na panství v době mezi osvícenstvím a počátky moderní éry. Zásluhou Věry Vlčkové, která rukopis objevila, přeložila a opatřila rozsáhlým poznámkovým aparátem, se tento zajímavý dokument mohl znovu vrátit k čtenářům. Pamětihodnosti panství Náchod nejsou jen kronikou úředníka, ale živým svědectvím o době proměn, loajality a kultury, kdy se z venkovského panství stávalo jedno z kulturních a politických center východních Čech.
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15,05 €

The Elsewhere Express (Paperback)


Embark on a magical journey in this uplifting and inspiring fantasy from the Sunday Times bestselling author of Water Moon - perfect for fans of Spirited Away, Dallergut Dream Department Store and The Starless Sea. DON'T MISS OUT ON THIS BEAUTIFUL LIMITED EDITION HARDBACK, featuring gorgeous illustrated endpapers with a scene you can colour in! Raya is a lost soul, going through the motions of life without a dream of her own. One night, on her subway ride home, Raya's thoughts wander too far. She wakes on the Elsewhere Express, a magical train that offers its passengers a sense of purpose, peace, and belonging. The journey is a chance for Raya to reimagine her life - but only if she finds her compartment before time runs out. Once aboard, Raya meets an intriguing artist named Q and together they race to find their place on the train, through a boarding car carpeted in meadow grass and along a dining carriage where passengers picnic on lilypads. But a mysterious stowaway has boarded with them, and with it a dark, malignant magic that threatens to destroy the train. The closer Raya comes to uncovering the stowaway's identity, the nearer she draws to the ultimate question: What is her life's true purpose - and is it a destination the Elsewhere Express can take her to?
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22,45 €

Departure(s)


Departure(s) is a work of fiction - but that doesn't mean it's not true. Departure(s) is the story of a man called Stephen and a woman called Jean, who fall in love when they are young and again when they are old. It is the story of an elderly Jack Russell called Jimmy, enviably oblivious to his own mortality. It is also the story of how the body fails us, whether through age, illness, accident or intent. And it is the story of how experiences fade into anecdotes, and then into memory. Does it matter if what we remember really happened? Or does it just matter that it mattered enough to be remembered? It begins at the end of life - but it doesn't end there. Ultimately, it's about the only things that ever really mattered: how we find happiness in this life, and when it is time to say goodbye.
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27,95 €

Heal Your Gut, Save Your Brain


Cognitive decline is not your destiny. You can improve your brain function through small steps taken every day. Heal Your Gut, Save Your Brain by gastroenterologist and health advocate Dr. Partha Nandi highlights the latest research on the gut-brain connection, giving you a clear protocol for maintaining brain health, and slowing or reducing the effects of neurodegenerative diseases as you age. This book details: THE VITAL GUT-BRAIN CONNECTION Discover the profound link between your gut and brain, and explore how this connection shapes your emotions, cognitive abilities, and overall mental health. NUTRITION'S ROLE IN GUT AND BRAIN HEALTH Unlock the secrets of a diet that nurtures your gut microbiome, paving the way for enhanced brain function, reduced inflammation, and a shield against cognitive decline. A NEW UNDERSTANDING OF LEAKY GUT SYNDROME Dive deep into the causes and consequences of leaky gut, or increased intestinal permeability, learning how it can trigger systemic inflammation and affect brain health. A HOLISTIC APPROACH Embrace Dr. Nandi's five pillars of health - nutrition, movement, community, spirituality, and purpose - for a comprehensive strategy that nurtures gut health and, in turn, boosts cognitive function and overall vitality. THE IMPACT OF THE MICROBIOME ON NEURODEGENERATION Learn about the critical role of your gut's microbiome in preventing and battling neurodegenerative diseases like stroke, Alzheimer's, and Parkinson's.
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28,95 €

The Flower Bearers


'A beautiful and immensely powerful book about love, grief and finding a way to be in a forever altered world' Julia Samuel'The Flower Bearers goes to some dark places, but there is joy, too . . . simultaneously a love story, a portrait of sisterhood and a visceral depiction of violence, loss and emotional devastation' Guardian 'Lyrical and life-affirming . . . A deeply felt, expressive book that battles with despair and hope, ever searching for the latter' ScotsmanOn September 24, 2021, Rachel Eliza Griffiths married her husband, the novelist Salman Rushdie. On the same day, hundreds of miles away, her closest friend, Kamilah Aisha Moon, who was expected to speak at the wedding, died suddenly. Eleven months later, as Rachel Eliza was learning to exist without her, a brutal attack nearly killed her husband. As trauma compounded trauma, Rachel Eliza realized that to survive her heartbreak, she would need to mourn not only her friend, but the woman she had been on her wedding day. And so Rachel Eliza chronicles her seventeen years of friendship with Aisha. From the moment they met in a college library, she knew she had found a soul sister. Their life together was filled with music: they danced to records in their apartments and skipped from one sticky jazz bar to another. Sitting side-by-side at poetry circles, reading Toni Morrison and Alice Walker, marching through Harlem protesting lost Black lives, Rachel Eliza drew inspiration and strength from her friend. Together they learnt to embrace themselves, as writers, artists, and Black women. Rachel Eliza interweaves this love story with another, that of her relationship with Rushdie, of the challenges they have faced and the depth of their connection. Celebrating the ways that these two extraordinary people have transformed her life, she reflects on the beauty and pain that come with opening oneself fully to love.
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29,49 €

The Killing Age


We have ignored a fundamental truth at the heart of modern world history – with dramatic consequences for our age of polycrisis.The years we most associate with human progress – the Enlightenment, the birth of democracies, the Industrial Revolution – were at the same time catastrophically destructive.In this trailblazing work of revisionist history, Professor Clifton Crais argues that the growth of global capitalism between 1750 and the early 1900s should be seen not as the Anthropocene, but the Mortecene: the Age of Killing. Killing brought the world together and tore it apart, as profiteering merchant warriors committed mass-scale slaughter of humans and animals across Africa, Asia and the Americas. This new network of global connections and economies killed tens of millions of people and sparked an environmental crisis that remains the most pressing catastrophe facing the world today.Drawing on years of scholarship and a range of new sources, THE KILLING AGE turns our vision of past and present on its head, illuminating the Mortecene in all its horror: how it has shaped who we are, what we value, what we fear, and the precarious present we inhabit today.
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39,49 €

Parenting Anxiety


The first evidence-based guide to empowering both children and parents to battle their anxietyEven before the pandemic, anxiety disorders were increasing in children and young people. As many parents know only too well, they have since increased exponentially, wreaking havoc on the emotional wellbeing of a whole generation. But is there anything parents can do to help their children, especially when they’re struggling to manage anxiety themselves? Absolutely – and this book will show you how. Offering parents a clear, accessible roadmap from constantly fearing the next meltdown to a enjoying calmer, happier life for your entire family, Parenting Anxiety is full of expert, evidence-backed advice – not only to help children soothe their anxieties, but helping parents manage their own, too. Written by Dr Meredith Elkins – a Harvard Medical School-trained paediatrician and anxiety specialist – the techniques in this book are grounded in cognitive behaviour therapy and backed up by scientific evidence, offering you reliable methods to strengthen your family’s anxiety-fighting abilities. Tackling one of the hardest issues facing families today with wisdom, warmth and humour, this is an essential handbook with advice that will help every modern parent.
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22,99 €

The Life Inside


Now a major BBC drama, Waiting for the Out. A unique insight into survival behind bars, inherited shame and some of life’s most pressing questions. An Irish Times and The i Book of the Year'Tense and intimate . . . an education' – Geoff Dyer'Authentic, fascinating and deeply moving' – Terry WaiteAndy West teaches philosophy in prisons. Every time he steps behind bars, he also confronts his inherited shame: his father, uncle and brother all spent time inside. While Andy has built a different life for himself, he still fears that their fate will also be his. Every day he has conversations with prisoners about their lives. Together they tackle the big questions: Can someone in prison be more free than someone outside? Would we ever be good if we never felt shame? What makes a person worthy of forgivenes? s he discusses pressing questions of truth, identity and hope with his students, Andy searches for his own form of freedom too. Now a six-part BBC drama, 'Waiting for the Out', The Life Inside is an elegantly written and unforgettable memoir, offering a new insight into our stretched justice system, our failing prisons and the complex lives being lived inside. 'Inspiring' – The Observer'Enriching, sobering and at times heartrending' - Lenny Henry'A remarkable insight into prison life' – Amanda Brown'Expands both heart and mind' – Ciaran Thapar'A fascinating and enlightening journey . . . A legitimate page-turner' – 3:AM Magazine
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14,99 €

Politics and the Economy


In today's societies, political and economic issues are closely intertwined, and political philosophy has turned more and more to economic issues. This Element introduces some key questions of economic philosophy: How to think about the relation between political and economic power? Can markets be 'tamed'? Which values are embedded in the economy and how do those relate to political values? It answers these questions by considering arguments from three theoretical perspectives – liberal egalitarian approaches, neorepublicanism, and critical theory or socialist thought – explaining their different background assumptions but also shared grounds. To illustrate these topics, it zooms in on the future of work: How could work be made more just, democratic, and sustainable? In the conclusion, some implications for research strategies in economic philosophy are explored.
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24,49 €

How to Win at Chess


Written by Grandmaster Daniel King, How To Win At Chess introduces each piece and its moves, explains key principles such as check and how to open a game, before exploring tricks such as forks, pins and skewers. With a fresh, contemporary new design, it’s packed with graded test positions and training exercises to help young players improve their game as they progress through the book. What’s more, readers can brush up on the fascinating history of chess, with features on legendary matches and the greatest players, including the current world champion, Magnus Carlsen.Chess has been revolutionized in recent years – thanks to the success of Netflix’s world-beating The Queen’s Gambit, the rise of chess streaming on Twitch, the desire for self-improvement during lockdown, and the global appeal of Magnus Carlsen, the youngest player ever to top the world rankings – and its newfound popularity with young and old alike shows no sign of waning.
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12,99 €

Belsay


FROM THE MULTI-MILLION BESTSELLING AUTHOR OF HOLY ISLANDChristmas can be deadly…After a long year of crime-fighting, DCI Ryan and his team are looking forward to a peaceful Christmas filled with festive treats – including the occasional turkey stottie, or three. To celebrate a job well done, the entire team are treated to a party at beautiful Belsay Hall, a spectacular country estate on the outskirts of the city. But, when their dinner is interrupted by the untimely arrival of a dead body, they’re reminded that crime never sleeps – and nor do the secrets within the walls of Belsay. It's time to find out who’s been naughty or nice…Murder and mystery are peppered with romance and humour in this fast-paced crime whodunnit, set amidst the spectacular Northumbrian landscape. ---------------------------------PRAISE FOR LJ ROSS"LJ Ross is the queen of Kindle" - Sunday Telegraph"She keeps company with the best mystery writers" - The Times"Holy Island is a blockbuster" - Daily Express"A literary phenomenon" - Evening Chronicle
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13,49 €

Mrs Hudson and the Belladonna Inheritance


London is sweltering and housemaid Flotsam longs for a break from the oppressive heat, although housekeeper Mrs Hudson remains unruffled. However, Baker Street is about to be consumed by an extremely weighty matter: the last Will and Testament of armaments tycoon Charles Belladonna. Belladonna left his considerable fortune to an only son who went missing, stolen from his cot, years before. Now not one but seven young men appear, each claiming to be the long-lost heir. The tangled case draws the War Office's attention, and a demand for Mr Sherlock Holmes's assistance. Only the razor-sharp minds above and below stairs at Baker Street stand a chance of uncovering the truth and foiling the sinister forces at work. For readers who treasure Conan Doyle, the Holmes & Hudson series offers a loving homage, enriched by fresh voices in the Holmes and Watson household.
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29,49 €

The Secret Life of the Hotel


Ever wondered what goes on behind the scenes in hotels? Hotels represent nations, hosting visiting monarchs, politicians, and diplomats. Hotels underpin global networks of travel and communication, on which national and international prosperity have increasingly depended since the end of the First World War. Yet hotels are also places where people can be anonymous; where murderers and thieves mix with adulterers and con artists; and where prejudice finds expression in who is refused access, and in the forms of ‘service’ provided by staff in the lowest-paid roles. The Secret Life of the Hotel: Sex, Crime and Protest in British Guesthouses Since 1918 is the first book to uncover how hotels entrenched inequality, prejudice, and exploitation in Britain’s tourist sector, and in wider society and culture, during the 20th century. Eloise Moss delves into hotel murders, swindles, and scandals, including the history of Agatha Christie’s disappearance in 1926, the ‘Margate Hotel Murder’, and the divorce of Wallis Simpson in 1936 so she could marry King Edward VIII. Moss’s exploration of the hotel also shines a light on the fight against the colour bar, the formation of the British civil rights movement, and the visit to London of Martin Luther King Jr. The Secret Life of the Hotel uniquely tells the story of Britain’s relationship with the world during the 20th century through the prism of its hotels, showing how their infrastructure and ‘welcome’ had profound consequences for women, people of colour, LGBTQ+ citizens, and people with disabilities.
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26,99 €

The Swell


Two sisters. A shipwreck. A story demanding to be told . . . Iceland, 1910. In the middle of a severe storm two sisters - Freyja and Gudrún - rescue a mysterious, charismatic man from a shipwreck near their remote farm. Sixty-five years later, a young woman - Sigga - is spending time with her grandmother when they learn a body has been discovered on a mountainside near Reykjavik, perfectly preserved in ice. Moving between the turn of the 20th century and the 1970s as a dark mystery is unravelled, The Swell is a spellbinding, beautifully atmospheric read, rich in Icelandic myth.
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16,45 €

One London Day


One city, one day, and a battle of wills reaches boiling pointJoseph Severin, a respectable North London businessman, has a lucrative side job. He's doing the books, old school (because these days the only trail you can't trace is a paper one) for a rogue MI5 outfit, the Shadows, headed by psychopathic Sebastien. However, when the game is rumbled, Sebastien sends hitman Mr Phipps to kill Severin and get those books back. The spider web of collateral damage will be extensive, taking in Lottie, for whom Severin has developed a sudden, wild passion; Sonya, a Russian escort with a desperate deadline; and at MI5, the ambitious Ellerby, who has them all in her sights. It's the hottest summer in fifty years and in the shadows, a deadly domino effect is about to spill out into the harsh light of day. An earlier version of this book was published as One London Day by C.C. Humphreys, now expanded and revised 2026.
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25,49 €

Night breaks apart, like pomegranate seeds in my palm


Aakriti Kuntal wields language like a blade and a balm, carving out poetry that is urgent and unafraid to ask what it means to exist. What does it mean to exist within language—to shape it, and in turn, to be shaped by it? In Night breaks apart, like pomegranate seeds in my palm, Aakriti Kuntal crafts poems that unravel at the edges of self and myth, where language is neither home nor escape, but a threshold to something more elemental. Her verses move like water rolling and sifting through sediment, shifting between dream and flesh. Through intimate confessions and stark observations, she confronts the absurdity of suffering, the weight of the body, and the vast, unknowable machinery of the universe. Each poem resists easy meaning, instead offering raw honesty: language as both wound and salve. For readers drawn to the introspective and the experimental, Kuntal’s poetry echoes the emotional depth of Ocean Vuong and the intellectual play of Anne Carson. This collection is for those who seek poetry not as answers, but as an experience—visceral, and unafraid to press against the limits of being.
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22,99 €

Two Women Living Together


At some point between living alone and becoming single, Hwang Sunwoo and Kim Hana found each other, and decided to live together in a nice apartment where their four cats would finally have the freedom to run around. Together they became a family - and redefined it. At a time housing costs have skyrocketed whilst the birth rates plummets, these two independent Korean women in their late forties share their views on society and its expectations of them. And, intent neither to marry or to live alone, they reflect on the comfort of their cohabiting friendship as it blossoms into a life full of joy and meaning. Quietly radical, full of warmth and wit, Two Women Living Together celebrates carving out your own path, cats, female friendship, and a different kind of family.
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25,95 €

The Book of Joy


Two spiritual giants. Seven days. One timeless question. 'The ultimate source of happiness is within us.' DALAI LAMA 'We grow in kindness when our kindness is tested.' DESMOND TUTU Archbishop Desmond Tutu and the Dalai Lama were friends for many, many years. Between them, they have endured exile, violence and oppression. And in the face of these hardships, they continued to radiate compassion, humour and above all, joy. To celebrate His Holiness's eightieth birthday, Archbishop Tutu travelled to the Dalai Lama's home in Dharamsala. The two men spent a week discussing a single burning question: how do we find joy in the face of suffering? This book is a gift from two of the most important spiritual figures of our time. Full of love, warmth and hope, The Book of Joy offers us the chance to experience their journey from first embrace to final goodbye.
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18,45 €

Najpredávanejší autori v tejto kategórii: Dominik Dán, Joanne K. Rowling, Elle Kennedy, Freida McFadden, Lucinda Riley.